A signature predicting poor prognosis in gastric and ovarian cancer
نویسندگان
چکیده
Affiliations: Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia 4 Molecular Genomics Core Facility, Peter MacCallum Cancer Centre, East Melbourne, Australia National ICT Australia (NICTA), The University of Melbourne, Parkville, Australia Department of Pathology Peter MacCallum Cancer Centre, East Melbourne, Australia Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore Cellular and Molecular Research, National Cancer Centre, Singapore
منابع مشابه
stromal - response . cancer represents a coordinated macrophage and A signature predicting poor prognosis in gastric and ovarian
متن کامل
A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response.
PURPOSE Gene-expression profiling has revolutionized the way we think about cancer and confers the ability to observe the synchronous expression of thousands of genes. The use of putative genome-level expression profiles has allowed biologists to observe the complex interactions of genes that constitute recognized biologic pathways. We used gastric and ovarian datasets to identify gene-expressi...
متن کاملActivation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer.
AIM We aimed to investigate the clinical significance of the activation of Yes-Associated Protein 1 (YAP1), a key downstream effector of Hippo tumor-suppressor pathway, in ovarian cancer. MATERIALS AND METHODS A gene expression signature reflecting activation of YAP1 was developed from gene expression data of 267 samples from patients with ovarian cancer. A refined ovarian cancer YAP1 signatu...
متن کاملSurvival in Nonmetastatic Gastric Cancer Patients
Background & Aims: Gastric carcinoma is the second most frequent cancer worldwide. Adjuvant treatment of gastric cancer varies worldwide; many differences have been observed in their clinical and pathological features, and survival rate. The aim of this study was to determine clinical and pathological features, and survival rate in a group of patients in south-east of Iran. Methods: Patient rec...
متن کاملPrognostic Value of microRNA Signature in Patients with Gastric Cancers
The occurrence of lymph node metastases (LNM) after endoscopic submucosal dissection (ESD) in patients with gastric cancer (GC) leads to poor prognosis. However, few biomarkers are available to predict LNM in GC patients. Thus, we measured expression of 6 cancer-related miRNAs using real-time RT-PCR in 102 GC samples that were randomized into a training set and a testing set (each, 51 cases). U...
متن کامل